My research is directed
towards understanding the neural and psychological
interface between motivation and cognition,-
or how rewarding stimuli influence learning. My
working hypothesis is that goal directed
behaviours and cognitive processes (such
as learning, memory and attention), as
part of a dynamic interactive system, reciprocally
modulate each other. In order to
investigate these process, I have adopted
two complementary approaches in my work. The
first is a theoretical overview of the
interaction between motivation and cognition
that examines how reward-related learning
is manifested in behaviour. The second
is an examination of specific neural systems
which may mediate the cognitive-motivational
interface. The majority of my research
focuses on animal models of drug addiction
as this disorder is characterized by a
breakdown in the 'normal' balance between
motivation and cognition. In our
lab, we investigate neural and psychological
processes underlying drug addiction using
a combination of neural and behavioural
techniques. These include multiple
measures of reward (conditioned place preference,
self-administration, intracranial self-stimulation),
analgesia (tail flick and formalin tests),
memory (radial arm maze, open field foraging),
motivation (sucrose consumption, transmission
of food preference) and impulsivity (delay
discounting, go/no-go, risk-taking) to
name a few. Neural measures include
post-mortem assessment of neurotoxin lesions,
intracranial drug injections, electrophysiological
recordings, long-term potentiation, corticosterone
assays, and receptor binding autoradiography. |